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He & She MD NAD+ at a Glance
| Our Rating | 3.9 / 5 |
|---|---|
| Best For | One price for injection, cream or spray |
| Formats | Injection, topical cream, nasal spray |
| Price | $149/mo on a 12-month supply |
| Membership Fee | None |
| Provider Access | Unlimited messaging while on the program |
| Medication Type | Compounded NAD+ (not FDA-approved) |
What Is He & She MD NAD+?
He & She MD is a telehealth practice whose NAD+ program is built around choice. Instead of one delivery method, it offers the same NAD+ therapy as a subcutaneous injection, a topical cream or a nasal spray — and charges the same flat monthly rate whichever you pick. Two of those three options are needle-free, which is rare among NAD+ providers.
The pricing model is simple: $149 a month, locked in on a 12-month supply, with no membership fee and no add-on charges. Unlimited messaging with a provider is included for as long as you stay on the program, so dose or format questions do not cost extra.
Formats matter because they absorb differently. Injections put NAD+ directly into tissue, while creams and sprays trade some absorption for convenience. Whichever you choose, the product is compounded rather than FDA-approved; the FDA’s compounding Q&A explains that the agency does not review compounded drugs for safety or effectiveness before they are sold.
Pros & Cons
Pros
- Injection, cream, or nasal spray — your choice
- Two needle-free options (cream and nasal spray), rare in this market
- One flat $149/mo price across every format, locked on a 12-month supply
- No membership fee and no hidden costs
- Unlimited provider messaging for as long as you are on the program
Cons
- Compounded NAD+ — not an FDA-approved finished drug product
- The $149/mo rate is locked on a 12-month supply ($1,788/yr)
How He & She MD NAD+ Works
Choose your format
Pick injection, cream or nasal spray — the price is the same, so the choice is about comfort and absorption.
Medical intake
Complete an online health questionnaire that a licensed provider reviews before prescribing.
Prescription and shipping
If approved, your NAD+ is compounded and shipped to your door.
Message your provider
Use unlimited messaging to ask about dosing, side effects or switching formats.
Safety & What to Know
Each He & She MD format brings its own minor side effects. Injections can leave redness or tenderness at the site, the cream can irritate sensitive skin, and the nasal spray may cause a stuffy or runny nose. Flushing, nausea and headaches have also been reported with NAD+ generally. Patch-test the cream on a small area first if your skin reacts easily.
Disclose all medications and health conditions in your intake, and raise concerns through the unlimited messaging rather than adjusting your dose on your own. If you are pregnant or breastfeeding, NAD+ is not well studied and most providers will advise against it.
He & She MD NAD+ Pricing
| Monthly Rate | $149/mo, any format |
|---|---|
| Commitment | 12-month supply |
| Annual Cost | $1,788 |
| Hidden Costs | None advertised |
The $149 figure is the per-month rate on a 12-month supply, so it is a year-long commitment of about $1,788 rather than a month-to-month price. Make sure you are comfortable with that before you check out.
Who He & She MD NAD+ Is For
A good fit if you
- Want a needle-free NAD+ option
- Like one predictable price regardless of format
- Value unlimited provider messaging
- Are ready to commit to a full year
Look elsewhere if you
- Want to try NAD+ for a single month first
- Want the highest-absorption format at the lowest price
- Prefer a results-based refund guarantee
How He & She MD NAD+ Compares
BettermeRx starts lower and backs its plans with a refund guarantee, but offers only two formats. System also gives a nasal-or-injection choice with lower first-month prices, though it shows ongoing pricing only during intake. He & She MD is the pick when format flexibility, including a cream, matters more than a short commitment. See the full field in our best NAD+ therapy providers guide.
Frequently Asked Questions
Our Verdict
★ 3.9 out of 5
He & She MD is the most flexible NAD+ program we reviewed: three formats, one flat price and unlimited provider messaging. The 12-month supply is the catch, so it suits people who already know they want NAD+ long term rather than those still experimenting.
See the full Best NAD+ Therapy Providers ranking →
Reviewed by
Dr. Lisa ChenHealth & Wellness Editor
Dr. Lisa Chen holds a Doctor of Pharmacy (PharmD) from UCSF and has 8 years of clinical experience in patient care and health education. She specializes in reviewing digital health platforms, wellness products, and nutrition services. Dr. Chen consults with a panel of MDs and registered dietitians to ensure all health content meets clinical accuracy standards.